Induction of G(2)/M arrest and inhibition of c-myc and p53 transcription by WP631 in Jurkat T lymphocytes.

@article{Villamarn2002InductionOG,
  title={Induction of G(2)/M arrest and inhibition of c-myc and p53 transcription by WP631 in Jurkat T lymphocytes.},
  author={S. Villamar{\'i}n and N. Ferrer-Miralles and Sylvia Mansilla and W. Priebe and J. Portugal},
  journal={Biochemical pharmacology},
  year={2002},
  volume={63 7},
  pages={
          1251-8
        }
}
WP631, a new DNA-binding drug that bisintercalates into DNA with high affinity, seems to be highly cytotoxic against Jurkat T lymphocytes. The purpose of this study was to gain new insights into the mechanisms by which WP631 halts proliferation in this cell type. Treating Jurkat cells with nanomolar concentrations of WP631 produced G(2)/M arrest, inhibited the transcription of c-myc and p53 genes, and induced limited apoptosis during the duration of treatment. Suppression of c-myc and p53… Expand
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