Induction of FosB/DeltaFosB in the brain stress system-related structures during morphine dependence and withdrawal.

@article{Nuez2010InductionOF,
  title={Induction of FosB/DeltaFosB in the brain stress system-related structures during morphine dependence and withdrawal.},
  author={Cristina Nu{\~n}ez and F{\'a}tima Mart{\'i}n and Anna F{\"o}ldes and M Luisa Laorden and Krisztina Kov{\'a}cs and M Victoria Milan{\'e}s},
  journal={Journal of neurochemistry},
  year={2010},
  volume={114 2},
  pages={475-87}
}
The transcription factor DeltaFosB is induced in the nucleus accumbens (NAc) by drugs of abuse. This study was designed to evaluate the possible modifications in FosB/DeltaFosB expression in both hypothalamic and extrahypothalamic brain stress system during morphine dependence and withdrawal. Rats were made dependent on morphine and, on day 8, were injected with saline or naloxone. Using immunohistochemistry and western blot, the expression of FosB/DeltaFosB, tyrosine hydroxylase (TH… CONTINUE READING