Induction of Expansion and Folding in Human Cerebral Organoids.

  title={Induction of Expansion and Folding in Human Cerebral Organoids.},
  author={Y. L. Li and Julien Muffat and Attya Omer and Irene Bosch and Madeline A Lancaster and Mriganka Sur and Lee Gehrke and Juergen A. Knoblich and Rudolf Jaenisch},
  journal={Cell stem cell},
  volume={20 3},
An expansion of the cerebral neocortex is thought to be the foundation for the unique intellectual abilities of humans. It has been suggested that an increase in the proliferative potential of neural progenitors (NPs) underlies the expansion of the cortex and its convoluted appearance. Here we show that increasing NP proliferation induces expansion and folding in an in vitro model of human corticogenesis. Deletion of PTEN stimulates proliferation and generates significantly larger and… CONTINUE READING
Recent Discussions
This paper has been referenced on Twitter 64 times over the past 90 days. VIEW TWEETS

From This Paper

Topics from this paper.


Publications referenced by this paper.
Showing 1-10 of 49 references

Autism-epilepsy phenotype

  • M. Marchese, V. Conti, +6 authors F. Sicca
  • 2014
Highly Influential
6 Excerpts

Similar Papers

Loading similar papers…