Induction of Epstein-Barr virus lytic cycle by tumor-promoting and non-tumor-promoting phorbol esters requires active protein kinase C.

@article{Davies1991InductionOE,
  title={Induction of Epstein-Barr virus lytic cycle by tumor-promoting and non-tumor-promoting phorbol esters requires active protein kinase C.},
  author={Albert Davies and Roger J. A. Grand and Fred J. Evans and Alan B. Rickinson},
  journal={Journal of virology},
  year={1991},
  volume={65 12},
  pages={6838-44}
}
Exposure to the tiglian 12-O-tetradecanoylphorbol-13-acetate (TPA) represents one of the most efficient and widely used protocols for inducing Epstein-Barr virus (EBV)-infected cells from latent into lytic cycle. Since TPA is both a potent tumor promoter and a potent activator of the cellular protein kinase C (PKC), we sought to determine whether either of these activities was closely linked to EBV lytic cycle induction. A panel of TPA structural analogs, encompassing tiglians with different… CONTINUE READING

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Showing 1-10 of 37 references

Epstein - Barr virus and its replication , p . 1889 - 1920

  • B. N. Fields, D. M. Knipe, M. Kishishita, J. Luka, B. Vroman, J. E. Poduslo
  • 1990

Epstein - Barr virus - infected B cells persist in the circulation of acyclovir - treated virus carriers

  • L. S. Young, R. Lau, +8 authors P. J. Farrell
  • Int . J . Cancer
  • 1989

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