Induction of DNA damage signaling by oxidative stress in relation to DNA replication as detected using "click chemistry".

@article{Zhao2011InductionOD,
  title={Induction of DNA damage signaling by oxidative stress in relation to DNA replication as detected using "click chemistry".},
  author={Haishuang Zhao and Jurek W. Dobrucki and Paulina Rybak and Frank Traganos and H Dorota Halicka and Zbigniew Darzynkiewicz},
  journal={Cytometry. Part A : the journal of the International Society for Analytical Cytology},
  year={2011},
  volume={79 11},
  pages={897-902}
}
Induction of DNA damage by oxidants such as H(2) O(2) activates the complex network of DNA damage response (DDR) pathways present in cells to initiate DNA repair, halt cell cycle progression, and prepare an apoptotic reaction. We have previously reported that activation of Ataxia Telangiectasia Mutated protein kinase (ATM) and induction of γH2AX are among the early events of the DDR induced by exposure of cells to H(2) O(2) , and in human pulmonary carcinoma A549 cells, both events were… CONTINUE READING

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Induction of DNA damage by oxidants such as H(2 ) O(2 ) activates the complex network of DNA damage response ( DDR ) pathways present in cells to initiate DNA repair , halt cell cycle progression , and prepare an apoptotic reaction .
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