Induction of DMBT1 expression by reduced ERK activity during a gastric mucosa differentiation-like process and its association with human gastric cancer.

@article{Kang2005InductionOD,
  title={Induction of DMBT1 expression by reduced ERK activity during a gastric mucosa differentiation-like process and its association with human gastric cancer.},
  author={Weiqun Kang and Ole Haagen Nielsen and Claus Fenger and Graham Leslie and Uffe Holmskov and Kenneth B. M. Reid},
  journal={Carcinogenesis},
  year={2005},
  volume={26 6},
  pages={
          1129-37
        }
}
Abnormalities in the expression of DMBT1 (deleted in malignant brain tumors 1) have been implicated in the development of esophageal, gastric and colorectal cancers of the alimentary tract, but the underlying mechanism remains unclear. In the present study, using the gastric cell line AGS, we identified two intracellular signaling molecules protein kinase C (PKC) and extracellular signal-related kinase (ERK). They mediated both the phorbol myristate acetate (PMA) downregulation of DMBT1… CONTINUE READING

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