Induction of DKK1 by ox-LDL negatively regulates intracellular lipid accumulation in macrophages.

@article{Zhang2015InductionOD,
  title={Induction of DKK1 by ox-LDL negatively regulates intracellular lipid accumulation in macrophages.},
  author={Yu Zhang and Cheng Min Ge and Lin Wang and Xinxin Liu and Yifei Chen and Mengmeng Li and Mei Zhang},
  journal={FEBS letters},
  year={2015},
  volume={589 1},
  pages={
          52-8
        }
}
Dickkopf1 (DKK1), a canonical Wnt/β-catenin pathway antagonist, is closely associated with cardiovascular disease and adipogenesis. We performed an in vitro study to determine whether oxidized low-density lipoprotein (ox-LDL) increased the expression of DKK1 in macrophages and whether β-catenin and liver X receptor α (LXRα) were involved in this regulation. Induction of DKK1 expression by ox-LDL decreased the level of lectin-like oxidized low-density lipoprotein receptor-1 (LOX-1) via a Wnt… CONTINUE READING
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