Induction of Cross-Reactive Serum Neutralizing Antibody


or postnatally with human rotavirus D (serotype 1) were tested by plaque reduction neutralization assay for antibody to bovine rotavirus and to three serotypes of human rotavirus. Homologous antibody developed in all animals, but antibody to heterologous rotaviruses developed mainly in animals exposed in utero to bovine rotavirus. The development of heterologous antibody may explain the immunological implications for cross-protection, previously observed between bovine and human rotavirus in experimentally infected calves.

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@inproceedings{Wyatt2003InductionOC, title={Induction of Cross-Reactive Serum Neutralizing Antibody}, author={Richard Wyatt and Albert Z. Kapikian}, year={2003} }