Induction of Ceramide-mediated Apoptosis by the Anticancer Phospholipid Analog, Hexadecylphosphocholine*

@article{Wieder1998InductionOC,
  title={Induction of Ceramide-mediated Apoptosis by the Anticancer Phospholipid Analog, Hexadecylphosphocholine*},
  author={T. Wieder and C. Orfanos and C. Geilen},
  journal={The Journal of Biological Chemistry},
  year={1998},
  volume={273},
  pages={11025 - 11031}
}
The prototype of a new class of antiproliferative phospholipid analogs, hexadecylphosphocholine (HePC), has been shown to inhibit tumor growth and is currently used for the treatment of cutaneous metastases of mammary carcinomas. Although several cellular targets of HePC, e.g. protein kinase C and CTP:phosphocholine cytidylyltransferase, have been proposed, the mechanisms of HePC-induced anticancer activity are still unclear. Considering that the antiproliferative effect of HePC correlates with… Expand
158 Citations
Hexadecylphosphocholine inhibits phosphatidylcholine biosynthesis and the proliferation of HepG2 cells.
  • 29
  • PDF
Alterations in the homeostasis of phospholipids and cholesterol by antitumor alkylphospholipids
  • 43
Updates on functions of ceramide in chemotherapy-induced cell death and in multidrug resistance.
  • B. Ogretmen, Y. Hannun
  • Biology, Medicine
  • Drug resistance updates : reviews and commentaries in antimicrobial and anticancer chemotherapy
  • 2001
  • 100
Anticancer mechanisms and clinical application of alkylphospholipids.
  • 106
...
1
2
3
4
5
...

References

SHOWING 1-10 OF 45 REFERENCES
Bcl‐2 antagonizes apoptotic cell death induced by two new ceramide analogues
  • 34
Induction of apoptotic DNA damage and cell death by activation of the sphingomyelin pathway.
  • 427
  • PDF
...
1
2
3
4
5
...