Induction of Cell-Cell Fusion by Ebola Virus Glycoprotein: Low pH Is Not a Trigger

@inproceedings{Markosyan2016InductionOC,
  title={Induction of Cell-Cell Fusion by Ebola Virus Glycoprotein: Low pH Is Not a Trigger},
  author={Ruben M. Markosyan and Chunhui Miao and Yi-Min Zheng and Gregory B. Melikyan and Shan-Lu Liu and Fredric Cohen and Christopher F Basler},
  booktitle={PLoS pathogens},
  year={2016}
}
Ebola virus (EBOV) is a highly pathogenic filovirus that causes hemorrhagic fever in humans and animals. Currently, how EBOV fuses its envelope membrane within an endosomal membrane to cause infection is poorly understood. We successfully measure cell-cell fusion mediated by the EBOV fusion protein, GP, assayed by the transfer of both cytoplasmic and membrane dyes. A small molecule fusion inhibitor, a neutralizing antibody, as well as mutations in EBOV GP known to reduce viral infection, all… CONTINUE READING
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