Induction of CYP3A expression by dehydroepiandrosterone: involvement of the pregnane X receptor.

@article{Ripp2002InductionOC,
  title={Induction of CYP3A expression by dehydroepiandrosterone: involvement of the pregnane X receptor.},
  author={Sharon L. Ripp and Jennifer L Fitzpatrick and Jeffrey M. Peters and Russell A. Prough},
  journal={Drug metabolism and disposition: the biological fate of chemicals},
  year={2002},
  volume={30 5},
  pages={
          570-5
        }
}
Dehydroepiandrosterone (DHEA) is a steroid produced by the human adrenal gland. Administration of pharmacological doses of DHEA to rats changes expression of many genes, including the cytochrome P450 family members CYP4A1 and CYP3A23. It is known that induction of CYP4A expression by DHEA requires the peroxisome proliferator-activated receptor alpha (PPAR(alpha)). In the current study, PPAR(alpha)-null mice were used to examine the role of PPAR(alpha) in expression of CYP3A. In wild-type mice… CONTINUE READING

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