Induction of CYP1A1 and CYP1B1 in T-47D human breast cancer cells by benzo[a]pyrene is diminished by arsenite.

@article{Spink2002InductionOC,
  title={Induction of CYP1A1 and CYP1B1 in T-47D human breast cancer cells by benzo[a]pyrene is diminished by arsenite.},
  author={David C. Spink and Barbara H Katz and M. Mahmood Hussain and Barbara C. Spink and Susan J Wu and Ning Liu and Ronald Pause and L. Kaminsky},
  journal={Drug metabolism and disposition: the biological fate of chemicals},
  year={2002},
  volume={30 3},
  pages={262-9}
}
Polycyclic aromatic hydrocarbons (PAHs) and metals are often environmental cocontaminants, yet there have been relatively few studies of combined effects of PAHs and metals on cytochrome P450 (P450)-catalyzed metabolism. We examined the effects of NaAsO(2) in combination with benzo[a]pyrene (BAP) on CYP1A1 and CYP1B1 in T-47D human breast cancer cells by using estrogen metabolism as a probe of their activities. Exposure to BAP caused elevated rates of the 2- and 4-hydroxylation pathways of… CONTINUE READING
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