Induction of CYP1A by the N-imidazole derivative, 1-benzylimidazole.

  title={Induction of CYP1A by the N-imidazole derivative, 1-benzylimidazole.},
  author={Jos{\'e} Maria Navas and Antonio Chana and Bernardo Herrad{\'o}n and Helmut Segner},
  journal={Environmental toxicology and chemistry},
  volume={22 4},
Xenobiotics can induce cytochrome P4501A (CYP1A) by ligand binding to the aryl hydrocarbon receptor (AhR). Typical AhR ligands are polycyclic aromatic compounds with planar molecular conformation. The present work investigated the ability of the N-imidazole derivative, 1-benzylimidazole (BIM), to induce CYP1A in rainbow trout hepatocytes. Benzylimidazole… CONTINUE READING