Induction of COX-2 by LPS in macrophages is regulated by Tpl2-dependent CREB activation signals.

@article{Eliopoulos2002InductionOC,
  title={Induction of COX-2 by LPS in macrophages is regulated by Tpl2-dependent CREB activation signals.},
  author={Aristides G. Eliopoulos and Calin Dan Dumitru and C C Wang and Jeonghee Cho and Philip N Tsichlis},
  journal={The EMBO journal},
  year={2002},
  volume={21 18},
  pages={4831-40}
}
Macrophage activation by bacterial lipopolysaccharide (LPS) promotes the secretion of pro-inflammatory cytokines, such as tumor necrosis factor-alpha (TNF-alpha) and interleukin-1beta (IL-1beta), and of secondary mediators, such as leukotrienes and prostaglandins (PGs). Mice lacking the gene encoding the serine/threonine protein kinase Tpl2/Cot produce low levels of TNF-alpha in response to LPS because of an ERK-dependent post-transcriptional defect, and they are resistant to LPS/D… CONTINUE READING
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