Induction of CD40 on human endothelial cells by Alzheimer's beta-amyloid peptides.

@article{Tan1999InductionOC,
  title={Induction of CD40 on human endothelial cells by Alzheimer's beta-amyloid peptides.},
  author={Jun Tan and Terrence C. Town and Zhiming Suo and Yingji Wu and Shanjun Song and Amy Kundtz and Jessica Kroeger and James Humphrey and Fiona E. Crawford and Michael Mullan},
  journal={Brain research bulletin},
  year={1999},
  volume={50 2},
  pages={
          143-8
        }
}
Growing evidence suggests that beta-amyloid (Abeta) peptides play a central role in mediating vascular endothelium dysfunction, but the extent to which immune mechanisms are involved in this process remains unclear. To explore such mechanisms, we incubated cultured human aortic endothelial cells (HAEC) with freshly solublized Abeta and examined expression of a central immunoregulatory molecule, CD40, in these cells using reverse transcriptase-polymerase chain reaction, Western immunoblotting… CONTINUE READING

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