Induction of CD4-dependent cell fusion by the HTLV-III/LAV envelope glycoprotein

@article{Lifson1986InductionOC,
  title={Induction of CD4-dependent cell fusion by the HTLV-III/LAV envelope glycoprotein},
  author={Jeffrey D Lifson and Mark B. Feinberg and Gregory R. Reyes and Linda Rabin and Babak Banapour and Sekhar K. Chakrabarti and Bernard Moss and Flossie Wong-Staal and Kathelyn S. Steimer and Edgar G. Engleman},
  journal={Nature},
  year={1986},
  volume={323},
  pages={725-728}
}
Formation of syncytia, with progression to cell death, is a characteristic feature of in vitro cultures of susceptible cells infected with human T-lymphotropic virus type III/lymphadenopathy-associated virus (HTLV-III/LAV)1–3. Viral antigen-positive multi-nucleated giant cells have also been observed in histological sections from infected individuals4,5. In… CONTINUE READING