Induction of CD4 T cell memory by local cellular collectivity

@article{Polonsky2018InductionOC,
  title={Induction of CD4 T cell memory by local cellular collectivity},
  author={Michal Polonsky and Jacob Rimer and Amos Kern-Perets and Irina Zaretsky and Stav Miller and Chamutal Bornstein and Eyal David and Naama Meira Kopelman and Gil Stelzer and Ziv Porat and Benjamin Chain and Nir Friedman},
  journal={Science},
  year={2018},
  volume={360}
}
Cell differentiation is directed by signals driving progenitors into specialized cell types. This process can involve collective decision-making, when differentiating cells determine their lineage choice by interacting with each other. We used live-cell imaging in microwell arrays to study collective processes affecting differentiation of naïve CD4+ T cells into memory precursors. We found that differentiation of precursor memory T cells sharply increases above a threshold number of locally… CONTINUE READING
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