Induction of CD4 T cell memory by local cellular collectivity

  title={Induction of CD4 T cell memory by local cellular collectivity},
  author={Michal Polonsky and Jacob Rimer and Amos Kern-Perets and Irina Zaretsky and Stav Miller and Chamutal Bornstein and Eyal David and Naama Meira Kopelman and Gil Stelzer and Ziv Porat and Benjamin Chain and Nir Friedman},
Cell differentiation is directed by signals driving progenitors into specialized cell types. This process can involve collective decision-making, when differentiating cells determine their lineage choice by interacting with each other. We used live-cell imaging in microwell arrays to study collective processes affecting differentiation of naïve CD4+ T cells into memory precursors. We found that differentiation of precursor memory T cells sharply increases above a threshold number of locally… CONTINUE READING
Recent Discussions
This paper has been referenced on Twitter 146 times over the past 90 days. VIEW TWEETS

From This Paper

Figures, tables, results, connections, and topics extracted from this paper.
1 Extracted Citations
48 Extracted References
Similar Papers

Citing Papers

Publications influenced by this paper.

Referenced Papers

Publications referenced by this paper.
Showing 1-10 of 48 references

Similar Papers

Loading similar papers…