Induction of CD36 expression by oxidized LDL and IL-4 by a common signaling pathway dependent on protein kinase C and PPAR-gamma.

@article{Feng2000InductionOC,
  title={Induction of CD36 expression by oxidized LDL and IL-4 by a common signaling pathway dependent on protein kinase C and PPAR-gamma.},
  author={Jian Nan Feng and Jihong Han and S. Frieda A. Pearce and Roy L Silverstein and Antonio M. Gotto and David P. Hajjar and Andrew C. Nicholson},
  journal={Journal of lipid research},
  year={2000},
  volume={41 5},
  pages={688-96}
}
CD36, a class B scavenger receptor, is a macrophage receptor for oxidized low density lipoprotein (OxLDL) and may play a critical role in atherosclerotic foam cell formation. We have previously demonstrated that OxLDL, macrophage-colony stimulating factor (M-CSF), and interleukin-4 (IL-4) enhanced expression of CD36. The effect of OxLDL on CD36 is due, in part, to its ability to activate the transcription factor, PPAR-gamma (peroxisome proliferator activated receptor-gamma). Other PPAR-gamma… CONTINUE READING

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