Induction of C-X-C chemokine receptor type 7 (CXCR7) switches stromal cell-derived factor-1 (SDF-1) signaling and phagocytic activity in macrophages linked to atherosclerosis.

@article{Ma2013InductionOC,
  title={Induction of C-X-C chemokine receptor type 7 (CXCR7) switches stromal cell-derived factor-1 (SDF-1) signaling and phagocytic activity in macrophages linked to atherosclerosis.},
  author={Wanshu Ma and Yiwei Liu and Nicholas Ellison and Jianzhong Shen},
  journal={The Journal of biological chemistry},
  year={2013},
  volume={288 22},
  pages={
          15481-94
        }
}
  • Wanshu Ma, Yiwei Liu, +1 author Jianzhong Shen
  • Published in
    The Journal of biological…
    2013
  • Biology, Medicine
  • The discovery of CXCR7 as a new receptor for SDF-1 places many previously described SDF-1 functions attributed to CXCR4 in question, though whether CXCR7 acts as a signaling or "decoy" receptor has been in debate. It is known that CXCR7 is not expressed in normal blood leukocytes; however, the potential role of leukocyte CXCR7 in disease states has not been addressed. The aim of this study was to determine the expression and function of macrophage CXCR7 linked to atherosclerosis. Here, we show… CONTINUE READING

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    References

    Publications referenced by this paper.
    SHOWING 1-10 OF 36 REFERENCES

    Monocyte and macrophage dynamics during atherogenesis.

    VIEW 3 EXCERPTS
    HIGHLY INFLUENTIAL

    Beta-arrestin- but not G protein-mediated signaling by the "decoy" receptor CXCR7.

    CXCL12 / CXCR4 / CXCR7 chemokine axis and cancer progression

    VIEW 3 EXCERPTS