Induction of Broad-Based Immunity and Protective Efficacy by Self-amplifying mRNA Vaccines Encoding Influenza Virus Hemagglutinin.

@article{Brazzoli2016InductionOB,
  title={Induction of Broad-Based Immunity and Protective Efficacy by Self-amplifying mRNA Vaccines Encoding Influenza Virus Hemagglutinin.},
  author={Michela Brazzoli and Diletta Magini and Alessandra Bonci and Scilla Buccato and Cinzia Giovani and Roland Kratzer and Vanessa Zurli and Simona Mangiavacchi and Daniele Casini and Luis M Brito and Ennio de Gregorio and Peter W. Mason and Jeffrey B. Ulmer and Andrew J. Geall and Sylvie Bertholet},
  journal={Journal of virology},
  year={2016},
  volume={90 1},
  pages={332-44}
}
UNLABELLED Seasonal influenza is a vaccine-preventable disease that remains a major health problem worldwide, especially in immunocompromised populations. The impact of influenza disease is even greater when strains drift, and influenza pandemics can result when animal-derived influenza virus strains combine with seasonal strains. In this study, we used the SAM technology and characterized the immunogenicity and efficacy of a self-amplifying mRNA expressing influenza virus hemagglutinin (HA… CONTINUE READING
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