Induction of BIM, a Proapoptotic BH3-Only BCL-2 Family Member, Is Critical for Neuronal Apoptosis

@article{Putcha2001InductionOB,
  title={Induction of BIM, a Proapoptotic BH3-Only BCL-2 Family Member, Is Critical for Neuronal Apoptosis},
  author={Girish V. Putcha and Krista L. Moulder and Judith P. Golden and Philippe Bouillet and Jerry A Adams and Andreas Strasser and Eugene Malcolm Johnson},
  journal={Neuron},
  year={2001},
  volume={29},
  pages={615-628}
}
Sympathetic neuronal death induced by nerve growth factor (NGF) deprivation requires the macromolecular synthesis-dependent translocation of BAX from the cytosol to mitochondria and its subsequent integration into the mitochondrial outer membrane, followed by BAX-mediated cytochrome c (cyt c) release. The gene products triggering this process remain unknown. Here, we report that BIM, a member of the BH3-only proapoptotic subfamily of the BCL-2 protein family, is one such molecule. NGF… CONTINUE READING
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Bax of two reports describing BIM induction during trophic factor depri

  • G. V. Putcha, M. Deshmukh, E. M. Johnson, Jr.
  • 1999
Highly Influential
19 Excerpts

Role of Ca21 extends the commitment to neuronal death beyond cytochrome

  • T. Koike, D. P. Martin, E. M. Johnson, Jr.
  • 1989
Highly Influential
6 Excerpts

Inhibition 21(3): 854–864, 2001)

  • G. V. Putcha, M. Deshmukh, E. M. Johnson, Jr.
  • Although the reports do not address whether
  • 2000
Highly Influential
5 Excerpts

depolarization - and insulin - like growth factor I - mediated survival of Phosphatidylinositol 3 - kinase is required for the trophic , but not cerebellar granule cells

  • B. A. Tsui-Pierchala, G. V. Putcha, E. M. Johnson
  • J . Biol . Chem . J . Neurosci .
  • 2000
Highly Influential
4 Excerpts

Inhibition of phosphatidylinositol 3-kinase activity blocks Tsui-Pierchala

  • T. M. Miller, M. G. Tansey, E. M. Johnson, Jr., D. J. Creedon
  • J. Biol
  • 1997
Highly Influential
3 Excerpts

Bcl-2 family that promotes apoptosis

  • G.E, R. L. Moritz, R. J. Simpson, D. L. Vaux
  • EMBO J. 17,
  • 2000

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