Induction of B-chronic lymphocytic leukemia cell apoptosis by arsenic trioxide involves suppression of the phosphoinositide 3-kinase/Akt survival pathway via c-jun-NH2 terminal kinase activation and PTEN upregulation.

@article{RedondoMuoz2010InductionOB,
  title={Induction of B-chronic lymphocytic leukemia cell apoptosis by arsenic trioxide involves suppression of the phosphoinositide 3-kinase/Akt survival pathway via c-jun-NH2 terminal kinase activation and PTEN upregulation.},
  author={Javier Redondo-Mu{\~n}oz and Elizabeth Escobar-D{\'i}az and Mercedes Hern{\'a}ndez del Cerro and Atanasio Pandiella and Mar{\'i}a Jos{\'e} Terol and Jos{\'e} Antonio Garc{\'i}a-Marco and {\'A}ngeles Garc{\'i}a-Pardo},
  journal={Clinical cancer research : an official journal of the American Association for Cancer Research},
  year={2010},
  volume={16 17},
  pages={4382-91}
}
PURPOSE Arsenic trioxide (ATO) induces B-cell chronic lymphocytic leukemia (B-CLL) cell apoptosis in vitro. We sought to study the mechanism involved in this effect and whether ATO is suitable for combination therapies with protein kinase inhibitors. EXPERIMENTAL DESIGN B-CLL cells were isolated from the peripheral blood of 28 patients. Cell viability studies with ATO alone or in combination with kinase inhibitors were done by flow cytometry, Western blotting, and immunofluorescence analyses… CONTINUE READING
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