Induction of B-chronic lymphocytic leukemia cell apoptosis by arsenic trioxide involves suppression of the phosphoinositide 3-kinase/Akt survival pathway via c-jun-NH2 terminal kinase activation and PTEN upregulation.

Abstract

PURPOSE Arsenic trioxide (ATO) induces B-cell chronic lymphocytic leukemia (B-CLL) cell apoptosis in vitro. We sought to study the mechanism involved in this effect and whether ATO is suitable for combination therapies with protein kinase inhibitors. EXPERIMENTAL DESIGN B-CLL cells were isolated from the peripheral blood of 28 patients. Cell viability… (More)
DOI: 10.1158/1078-0432.CCR-10-0072

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@article{RedondoMuz2010InductionOB, title={Induction of B-chronic lymphocytic leukemia cell apoptosis by arsenic trioxide involves suppression of the phosphoinositide 3-kinase/Akt survival pathway via c-jun-NH2 terminal kinase activation and PTEN upregulation.}, author={Javier Redondo-Mu{\~n}{\'o}z and Elizabeth Escobar-D{\'i}az and Mercedes Hern{\'a}ndez del Cerro and Atanasio Pandiella and Mar{\'i}a Jos{\'e} Terol and Jos{\'e} Antonio Garc{\'i}a-Marco and {\'A}ngeles Garc{\'i}a-Pardo}, journal={Clinical cancer research : an official journal of the American Association for Cancer Research}, year={2010}, volume={16 17}, pages={4382-91} }