Induction of B-cell development in adult mice reveals the ability of bone marrow to produce B-1a cells.

@article{Dber2009InductionOB,
  title={Induction of B-cell development in adult mice reveals the ability of bone marrow to produce B-1a cells.},
  author={Sandra D{\"u}ber and Martin Hafner and Martina Krey and Stefan Lienenklaus and Bishnudeo Roy and Elias Hobeika and Michael Reth and Thorsten Buch and Ari Waisman and Karsten Kretschmer and Siegfried Weiss},
  journal={Blood},
  year={2009},
  volume={114 24},
  pages={4960-7}
}
To study B-cell development from bone marrow (BM), we generated recombination-activating gene 1 (Rag1)-targeted mice lacking mature lymphocytes. B-cell development can be induced in such mice by B cell-specific restoration of a functional Rag1 transcription unit. Follicular and marginal zone B cells populated the spleen when Rag1 expression was permitted. Notably, the peritoneal cavity was dominated by bona fide B-1a cells, as judged by surface markers and functional properties. These BM… CONTINUE READING
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