Induction of Autophagy in Axonal Dystrophy and Degeneration

@article{Wang2006InductionOA,
  title={Induction of Autophagy in Axonal Dystrophy and Degeneration},
  author={Q. Wang and Y. Ding and Stave Kohtz and N. Mizushima and I. M. Cristea and M. Rout and B. Chait and Y. Zhong and N. Heintz and Z. Yue},
  journal={The Journal of Neuroscience},
  year={2006},
  volume={26},
  pages={8057 - 8068}
}
  • Q. Wang, Y. Ding, +7 authors Z. Yue
  • Published 2006
  • Biology, Medicine
  • The Journal of Neuroscience
    • Autophagy is a highly regulated cellular mechanism for the bulk degradation of cytoplasmic contents. It has been implicated in a variety of physiological and pathological conditions relevant to neurological diseases. However, the regulation of autophagy in neurons and its role in neuronal and axonal pathology are not yet understood. Using transgenic mice producing green fluorescent protein-tagged autophagic marker microtubule-associated protein light chain 3 (GFP–LC3), we provide molecular… CONTINUE READING
    View on SFN
    jneurosci.org
    297 Citations
    Highly Influencial Citations
    9
    Background Citations
    133
    Methods Citations
    10
    Results Citations
    13
    297 Citations
    Citation Type

    Citation Type

    Neuronal autophagy: Going the distance to the axon
    • 55
    • PDF
    Essential role for autophagy protein Atg7 in the maintenance of axonal homeostasis and the prevention of axonal degeneration
    • 502
    • PDF
    Complex Roles of Constitutive Autophagy in the Neuron and the Axon: Protein Quality Control and Maintenance of Membrane Homeostasis
    Focal cerebral ischemia induces upregulation of Beclin 1 and autophagy-like cell death
    • 262
    Mechanisms of neuronal homeostasis: Autophagy in the axon
    • S. Maday
    • Biology, Medicine
    • Brain Research
    • 2016
    • 54
    • PDF
    Using genetic mouse models to study the biology and pathology of autophagy in the central nervous system.
    • 5
    • PDF
    Neuronal autophagy and axon degeneration
    • 14
    Disrupted Autophagy Leads to Dopaminergic Axon and Dendrite Degeneration and Promotes Presynaptic Accumulation of α-Synuclein and LRRK2 in the Brain
    • 193
    • PDF
    Induction of autophagy in neurite degeneration of mouse superior cervical ganglion neurons
    • 104
    Autophagy Induction and Autophagosome Clearance in Neurons: Relationship to Autophagic Pathology in Alzheimer's Disease
    • 833
    • PDF

    References

    SHOWING 1-10 OF 47 REFERENCES
    Extensive Involvement of Autophagy in Alzheimer Disease: An Immuno-Electron Microscopy Study
    • 1,122
    • PDF
    A Novel Protein Complex Linking the δ2 Glutamate Receptor and Autophagy Implications for Neurodegeneration in Lurcher Mice
    • 298
    Impairment of starvation-induced and constitutive autophagy in Atg7-deficient mice
    • 1,965
    • PDF
    In vivo analysis of autophagy in response to nutrient starvation using transgenic mice expressing a fluorescent autophagosome marker.
    • 1,990
    • PDF
    p62/SQSTM1 forms protein aggregates degraded by autophagy and has a protective effect on huntingtin-induced cell death
    • 2,534
    • Highly Influential
    • PDF
    Cytoskeletal elements are required for the formation and maturation of autophagic vacuoles
    • 160
    Lysosomal Turnover, but Not a Cellular Level, of Endogenous LC3 is a Marker for Autophagy
    • 907
    Autophagy Is Activated by Apoptotic Signalling in Sympathetic Neurons: An Alternative Mechanism of Death Execution
    • 451
    Huntingtin Aggregate-Associated Axonal Degeneration is an Early Pathological Event in Huntington's Disease Mice
    • 323
    • PDF
    Microtubules Facilitate Autophagosome Formation and Fusion of Autophagosomes with Endosomes
    • 375