Induction of Autophagy in Axonal Dystrophy and Degeneration

  title={Induction of Autophagy in Axonal Dystrophy and Degeneration},
  author={Q. Wang and Y. Ding and Stave Kohtz and N. Mizushima and I. M. Cristea and M. Rout and B. Chait and Y. Zhong and N. Heintz and Z. Yue},
  journal={The Journal of Neuroscience},
  pages={8057 - 8068}
  • Q. Wang, Y. Ding, +7 authors Z. Yue
  • Published 2006
  • Biology, Medicine
  • The Journal of Neuroscience
  • Autophagy is a highly regulated cellular mechanism for the bulk degradation of cytoplasmic contents. It has been implicated in a variety of physiological and pathological conditions relevant to neurological diseases. However, the regulation of autophagy in neurons and its role in neuronal and axonal pathology are not yet understood. Using transgenic mice producing green fluorescent protein-tagged autophagic marker microtubule-associated protein light chain 3 (GFP–LC3), we provide molecular… CONTINUE READING
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