Induction of Autophagy by Cystatin C: A Mechanism That Protects Murine Primary Cortical Neurons and Neuronal Cell Lines

@inproceedings{Tizon2010InductionOA,
  title={Induction of Autophagy by Cystatin C: A Mechanism That Protects Murine Primary Cortical Neurons and Neuronal Cell Lines},
  author={Belen Tizon and Susmita Sahoo and Haung Yu and S{\'e}bastien Gauthier and Asok R. Kumar and Panaiyur Mohan and Matthew J. Figliola and Monika Pawlik and Anders Grubb and Yasuo Uchiyama and Urmi Bandyopadhyay and Ana Mar{\'i}a Cuervo and Ralph A. Nixon and Efrat Levy},
  booktitle={PloS one},
  year={2010}
}
Cystatin C (CysC) expression in the brain is elevated in human patients with epilepsy, in animal models of neurodegenerative conditions, and in response to injury, but whether up-regulated CysC expression is a manifestation of neurodegeneration or a cellular repair response is not understood. This study demonstrates that human CysC is neuroprotective in cultures exposed to cytotoxic challenges, including nutritional-deprivation, colchicine, staurosporine, and oxidative stress. While CysC is a… CONTINUE READING
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