Induction of Apoptosis in a Macrophage Cell Line RAW 264.7 By Acemannan, a b-(1,4)-Acetylated Mannan LALITHA RAMAMOORTHY and IAN R. TIZARD

Abstract

Acemannan is a polydispersed b-(1,4)-linked acetylated mannan with antiviral properties. It is an immunomodulator, and studies in our laboratory have shown that it causes activation of macrophages. In the presence of IFNg, acemannan induced apoptosis in RAW 264.7 cells. These cells exhibited chromatin condensation, DNA fragmentation, and laddering… (More)

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