Induction of Apoptosis in MCF-7 Cells via Oxidative Stress Generation, Mitochondria-Dependent and Caspase-Independent Pathway by Ethyl Acetate Extract of Dillenia suffruticosa and Its Chemical Profile

Abstract

Dillenia suffruticosa, which is locally known as Simpoh air, has been traditionally used to treat cancerous growth. The ethyl acetate extract of D. suffruticosa (EADs) has been shown to induce apoptosis in MCF-7 breast cancer cells in our previous study. The present study aimed to elucidate the molecular mechanisms involved in EADs-induced apoptosis and to… (More)
DOI: 10.1371/journal.pone.0127441

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@inproceedings{Tor2015InductionOA, title={Induction of Apoptosis in MCF-7 Cells via Oxidative Stress Generation, Mitochondria-Dependent and Caspase-Independent Pathway by Ethyl Acetate Extract of Dillenia suffruticosa and Its Chemical Profile}, author={Yin Sim Tor and Latifah Saiful Yazan and J. B. Foo and Agustono Wibowo and Norsharina Ismail and Yoke Kqueen Cheah and Rasedee Abdullah and Maznah Ismail and Intan Safinar Ismail and Swee Keong Yeap and Siyaram Pandey}, booktitle={PloS one}, year={2015} }