Induction of AP-1 binding to intron 1 of SP-A1 and SP-A2 is implicated in the phorbol ester inhibition of human SP-A promoter activity.

@article{Hoover2000InductionOA,
  title={Induction of AP-1 binding to intron 1 of SP-A1 and SP-A2 is implicated in the phorbol ester inhibition of human SP-A promoter activity.},
  author={Russell R Hoover and Jelena Pavlovi{\'c} and Joanna Floros},
  journal={Experimental lung research},
  year={2000},
  volume={26 5},
  pages={303-17}
}
A deletional analysis of the SP-A1 promoter in NCI-H441 cells was performed to identify potential cis-acting elements involved in phorbol ester-mediated repression of human SP-A transcription. The phorbol ester TPA reduced SP-A1 and SP-A2 promoter activity to approximately 35% to 45% compared to that of control cells. The inhibitory effect of TPA was significantly reduced upon removal of the region +64/+394 relative to the SP-A1 transcription start site. Using NCI-H441 nuclear proteins… CONTINUE READING

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