Induction of A9 dopaminergic neurons from neural stem cells improves motor function in an animal model of Parkinson's disease.

@article{OKeeffe2008InductionOA,
  title={Induction of A9 dopaminergic neurons from neural stem cells improves motor function in an animal model of Parkinson's disease.},
  author={Fiona E O'Keeffe and Sarah A. Scott and Pam Tyers and Gerard W O'Keeffe and Jeffrey W. Dalley and Romain Zufferey and Maeve A Caldwell},
  journal={Brain : a journal of neurology},
  year={2008},
  volume={131 Pt 3},
  pages={630-41}
}
Neural stem cells (NSCs) are widely endorsed as a cell source for replacement strategies in neurodegenerative disease. However, their usefulness is currently limited by the inability to induce specific neurotransmitter phenotypes in these cells. In order to direct dopaminergic neuronal fate, we overexpressed Pitx3 in NSCs that were then exposed to E11 developing ventral mesencephalon (VM) in explant culture. This resulted in a significant potentiation of dopaminergic differentiation of the… CONTINUE READING
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Induction of a midbrain dopaminergic phenotype in Nurr1-overexpressing neural stem cells by type 1 astrocytes

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