Induction of 1C aldoketoreductases and other drug dose-dependent genes upon acquisition of anthracycline resistance.

@article{Veitch2009InductionO1,
  title={Induction of 1C aldoketoreductases and other drug dose-dependent genes upon acquisition of anthracycline resistance.},
  author={Zachary W Veitch and Baoqing Guo and Stacey L. Hembruff and Adam J. Bewick and Allan D Heibein and Jamei Eng and Stephanie Cull and David A. Maclean and Amadeo M Parissenti},
  journal={Pharmacogenetics and genomics},
  year={2009},
  volume={19 6},
  pages={477-88}
}
OBJECTIVES Recent studies suggest that tumor cells overexpressing aldoketoreductases (AKRs) exhibit increased resistance to DNA damaging agents such as anthracyclines. AKRs may induce resistance to the anthracycline doxorubicin by catalyzing its conversion to the less toxic 13-hydroxy metabolite doxorubicinol. However, it has not been established whether during selection for anthracycline resistance, AKR overexpression in tumor cells can be correlated with the onset or magnitude of drug… CONTINUE READING

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