Induction of 11beta-hydroxysteroid dehydrogenase type 1 but not -2 in human aortic smooth muscle cells by inflammatory stimuli.

@article{Cai2001InductionO1,
  title={Induction of 11beta-hydroxysteroid dehydrogenase type 1 but not -2 in human aortic smooth muscle cells by inflammatory stimuli.},
  author={Tian-quan Cai and Birming Wong and Steven S. Mundt and Rolf Thieringer and Samuel D. Wright and Anne Hermanowski-Vosatka},
  journal={The Journal of steroid biochemistry and molecular biology},
  year={2001},
  volume={77 2-3},
  pages={117-22}
}
The 11beta-hydroxysteroid dehydrogenase (11beta-HSD) enzymes catalyze the interconversion of active glucocorticoids (GC) with their inert metabolites, thereby regulating the functional activity of GC. While 11beta-HSD type 1 (11beta-HSD1) activates GC from their 11-keto metabolites, 11beta-HSD type 2 (11beta-HSD2) inactivates GC. Here we report that both of these enzymes are expressed in human aortic smooth muscle cells (SMC), and that 11beta-HSD1 is more abundant and is differentially… CONTINUE READING