Induction of −2 frameshift mutations within alternating GC sequences by carcinogens that bind to the C8 position of guanine residues Development of a specific mutation assay

@article{Bintz1990InductionO,
  title={Induction of −2 frameshift mutations within alternating GC sequences by carcinogens that bind to the C8 position of guanine residues Development of a specific mutation assay},
  author={R{\'e}gine Bintz and Robert P Fuchs},
  journal={Molecular and General Genetics MGG},
  year={1990},
  volume={221},
  pages={331-338}
}
Using a forward mutation assay we have previously found that N-2-acetylaminofluorene (AAF), a strong chemical carcinogen, induces a majority of frameshift mutations located at specific sequences called mutation hot spots. Among these hot spot sequences, the NarI sequence (GGCGCC), is specific for −2 frameshifts (GGCGCC) → GGCC). Interestingly, these frameshift mutations occur independently of a functional umuDC locus. Being interested in elucidating this mutation pathway we have developed a… CONTINUE READING