Induction of β-defensins by l-isoleucine as novel immunotherapy in experimental murine tuberculosis.

@article{RivasSantiago2011InductionO,
  title={Induction of β-defensins by l-isoleucine as novel immunotherapy in experimental murine tuberculosis.},
  author={Cesar Enrique Rivas-Santiago and Bruno Rivas-Santiago and David A Leon and J E Casta{\~n}eda-Delgado and Rogelio Hern{\'a}ndez Pando},
  journal={Clinical and experimental immunology},
  year={2011},
  volume={164 1},
  pages={80-9}
}
Tuberculosis is a worldwide health problem, and multidrug-resistant (MDR) and extensively multidrug-resistant (XMDR) strains are rapidly emerging and threatening the control of this disease. These problems motivate the search for new treatment strategies. One potential strategy is immunotherapy using cationic anti-microbial peptides. The capacity of l-isoleucine to induce beta-defensin expression and its potential therapeutic efficiency were studied in a mouse model of progressive pulmonary… CONTINUE READING

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