Induction of β-chemokine secretion by human brain microvessel endothelial cells via CD40/CD40L interactions

@article{Omari2004InductionO,
  title={Induction of β-chemokine secretion by human brain microvessel endothelial cells via CD40/CD40L interactions},
  author={Kakuri M Omari and Raymond Chui and Katerina Dorovini-Zis},
  journal={Journal of Neuroimmunology},
  year={2004},
  volume={146},
  pages={203-208}
}
beta-chemokines play an important role during the course of central nervous system (CNS) inflammation. Using primary cultures of human cerebral microvascular endothelial cells, we detected increased monocyte chemoattractant protein-1 (MCP-1) and regulated upon activation normal T cell expressed and secreted (RANTES) production following incubation with soluble CD40L. These results suggest a potential mechanism by which activated CD40L positive T cells may enhance beta-chemokine expression and… CONTINUE READING

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