Induction in Vascular Smooth Muscle Cells Mediated Monocyte Chemoattractant Protein-1 − α Pathways in Tumor Necrosis Factor-Convergence of Redox-Sensitive and Mitogen-Activated Protein Kinase Signaling

@inproceedings{Rengarajan2000InductionIV,
  title={Induction in Vascular Smooth Muscle Cells Mediated Monocyte Chemoattractant Protein-1 − α Pathways in Tumor Necrosis Factor-Convergence of Redox-Sensitive and Mitogen-Activated Protein Kinase Signaling},
  author={Kalpana Rengarajan and William R Taylor and Robert W. Alexander and K Kathy and Gilles W. De Keulenaer and Masuko Ushio-Fukai},
  year={2000}
}
Monocyte chemoattractant protein-1 (MCP-1) is an important component of the inflammatory response of the vessel wall and has been shown to be regulated by cytokines, such as tumor necrosis factora (TNF-a). However, the precise signaling pathways leading to MCP-1 induction have not been fully elucidated in vascular smooth muscle cells (VSMCs). Cytokine signal transduction involves protein kinases as well as reactive oxygen species (ROS). The relation between these 2 factors is not clear. In this… CONTINUE READING

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