Induction effect of phenobarbital on the carbamazepine to carbamazepine-10, 11-epoxide pathway in rhesus monkeys.

Abstract

The induction effect of phenobarbital on the carbamazepine to carbamazepine-10, 11-epoxide pathway was investigated in seven rhesus monkeys. Each animal received an 8-hr infusion of carbamazepine on days 1, 5 and 15. In addition, animals received an acute dose (130 mg) of phenobarbital on day 5 followed by 10 daily maintenance doses (40 mg). Plasma samples… (More)

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