Induction chemotherapy and cetuximab for locally advanced squamous cell carcinoma of the head and neck: results from a phase II prospective trial.

@article{Kies2010InductionCA,
  title={Induction chemotherapy and cetuximab for locally advanced squamous cell carcinoma of the head and neck: results from a phase II prospective trial.},
  author={Merrill S. Kies and F Christopher Holsinger and J Jack Lee and William N William and Bonnie S. Glisson and Heather Y Lin and Jan S. Lewin and L E Ginsberg and Katharine A Gillaspy and Erminia Massarelli and Lauren A. Byers and Scott Michael Lippman and Waun Ki Hong and A El-naggar and Adam Seth Garden and Vassiliki A. Papadimitrakopoulou},
  journal={Journal of clinical oncology : official journal of the American Society of Clinical Oncology},
  year={2010},
  volume={28 1},
  pages={8-14}
}
PURPOSE To determine the potential efficacy of combining cetuximab with chemotherapy in patients with advanced nodal disease, we conducted a phase II trial with induction chemotherapy (ICT) consisting of six weekly cycles of paclitaxel 135 mg/m(2) and carboplatin (area under the curve = 2) with cetuximab 400 mg/m(2) in week 1 and then 250 mg/m(2) (PCC). PATIENTS AND METHODS Forty-seven previously untreated patients (41 with oropharynx primaries; 33 men, 14 women; median age, 53 years… CONTINUE READING