Induction by lysophosphatidylcholine, a major phospholipid component of atherogenic lipoproteins, of human coronary artery smooth muscle cell migration.

@article{Kohno1998InductionBL,
  title={Induction by lysophosphatidylcholine, a major phospholipid component of atherogenic lipoproteins, of human coronary artery smooth muscle cell migration.},
  author={Masashi Kohno and Koji Yokokawa and Kenichi Yasunari and Mieko Minami and Hatsuyo Kano and Takao Hanehira and Junichi Yoshikawa},
  journal={Circulation},
  year={1998},
  volume={98 4},
  pages={353-9}
}
BACKGROUND The objectives of the present study were (1) to determine whether lysophosphatidylcholine (lyso-PC), a prominent component of oxidatively modified LDL, induces migration of human coronary artery smooth muscle cells (SMCs) and, if so, to clarify the mechanism, and (2) to investigate the possible interactions of lyso-PC and platelet-derived growth factor (PDGF)-BB, endothelin- (ET-1), adrenomedullin (AM), or vitamin E on SMC migration by the Boyden's chamber method. METHODS AND… CONTINUE READING
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