Induction by estradiol-17 beta of polycystic ovaries in the guinea pig.


In the present study we wished to develop a model for polycystic ovarian syndrome (PCOS) using the guinea pig, because this animal's cycle, compared to other rodent models, more closely emulates that of humans. Four silastic capsules, either empty or containing cholesterol or estradiol-17 beta, were placed subcutaneously for 48 h on Day 10 or 12 of the… (More)