Induction by antigen of intrathymic apoptosis of CD4+CD8+TCRlo thymocytes in vivo.

@article{Murphy1990InductionBA,
  title={Induction by antigen of intrathymic apoptosis of CD4+CD8+TCRlo thymocytes in vivo.},
  author={Kenneth M Murphy and Amy Heimberger and Dennis Y. Loh},
  journal={Science},
  year={1990},
  volume={250 4988},
  pages={1720-3}
}
In order to examine the mechanisms by which clonal deletion of autoreactive T cells occurs, a peptide antigen was used to induce deletion of antigen-reactive thymocytes in vivo. Mice transgenic for a T cell receptor (TCR) that reacts to this peptide contain thymocytes that progress from the immature to the mature phenotype. Intraperitoneal administration of the peptide antigen to transgenic mice results in a rapid deletion of the immature CD4+ CD8+ TCRlo thymocytes. Apoptosis of cortical… CONTINUE READING
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