Induction and subcellular localization of metallothionein in regenerating rat liver.

  title={Induction and subcellular localization of metallothionein in regenerating rat liver.},
  author={Kaoru Tsujikawa and Noboru Suzuki and Kimitaka Sagawa and Miyuki Itoh and Tomomi Sugiyama and Yasuhiro Kohama and Noriko Otaki and Midori Kimura and Takayuki Mimura},
  journal={European journal of cell biology},
  volume={63 2},
A highly specific antiserum against rat liver metallothionein (MT) was raised in a Japanese white rabbit. Using this anti-MT antiserum, we found that MT was localized in the nuclei as well as in the cytoplasm of hepatocytes in newborn rats. Since it is known that these cells are growing actively, we suspected that there was a relationship between the localization of MT in cell nuclei and the cell proliferation. Therefore, the induction and subcellular localization of MT were examined in rat… CONTINUE READING

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