Induction and subcellular localization of high-mobility group box-1 (HMGB1) in the postischemic rat brain.

@article{Kim2008InductionAS,
  title={Induction and subcellular localization of high-mobility group box-1 (HMGB1) in the postischemic rat brain.},
  author={Jung-Bin Kim and Chae-Moon Lim and Y Yu and Ja-Kyeong Lee},
  journal={Journal of neuroscience research},
  year={2008},
  volume={86 5},
  pages={1125-31}
}
High-mobility group box-1 (HMGB1) was originally identified as a ubiquitously expressed, abundant nonhistone DNA-binding protein. Recently, it was found to act as a cytokine-like mediator of delayed endotoxin lethality and of acute lung injury. Previously, we reported that HMGB1 is massively released extracellularly and plays a cytokine-like function in the postischemic brain. In the present study, we examined the expression profile and cellular distribution of HMGB1 in rat brain after… CONTINUE READING

Citations

Publications citing this paper.
Showing 1-10 of 79 extracted citations

High-mobility group protein box-1 and its relevance to cerebral ischemia.

Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism • 2010
View 7 Excerpts
Highly Influenced

Toll-like receptors in cerebral ischemic inflammatory injury

Journal of Neuroinflammation • 2011
View 14 Excerpts
Highly Influenced

Similar Papers

Loading similar papers…