Induction and reversibility of insulin resistance in rats exposed to exogenous D-fructose.

@article{Cancelas2008InductionAR,
  title={Induction and reversibility of insulin resistance in rats exposed to exogenous D-fructose.},
  author={J{\'e}sus Cancelas and Pavel Gonzx00E1lez Prieto and Marta Garc{\'i}a-Ar{\'e}valo and Ver{\'o}nica Sancho and Mar{\'i}a Luisa Villanueva-Pe{\~n}acarrillo and Wiily J Malaisse and Isabel Valverde},
  journal={Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme},
  year={2008},
  volume={40 7},
  pages={459-66}
}
Long-term exposure of normal rats to a fructose-enriched diet or drinking water is currently used as an animal model for experimental insulin resistance. The present study deals with a comparison between rats given access to either a fructose-enriched diet or fructose-enriched drinking water. In both situations, a decrease in food intake and body weight gain, and the induction of insulin resistance with intolerance to D-glucose despite increased secretory response to the aldohexose of insulin… CONTINUE READING

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