Induction and repression of peroxisome proliferator-activated receptor α transcription by coregulator ARA70

In an effort to understand transcriptional regulation by the peroxisome proliferator-activated receptor α (PPARα), we investigated the ability of a number of transcriptional coactivators to enhance PPARα:retinoic acid receptor (RXR) mediated transcription. We identified ARA70, a coactivator of the androgen receptor and PPARγ, as a ligand-enhanced… CONTINUE READING