Induction and regulation of the carcinogen-metabolizing enzyme CYP1A1 by marijuana smoke and delta (9)-tetrahydrocannabinol.

@article{Roth2001InductionAR,
  title={Induction and regulation of the carcinogen-metabolizing enzyme CYP1A1 by marijuana smoke and delta (9)-tetrahydrocannabinol.},
  author={Michael D Roth and Jose A Marques-Magallanes and Ming Yuan and Wenha Sun and Donald P Tashkin and Oliver Hankinson},
  journal={American journal of respiratory cell and molecular biology},
  year={2001},
  volume={24 3},
  pages={339-44}
}
Induction of the carcinogen-metabolizing enzyme cytochrome P4501A1 (CYP1A1) is a key step in the development of tobacco-related cancers. To determine if marijuana smoke activates CYP1A1, a murine hepatoma cell line expressing an inducible CYP1A1 gene (Hepa-1) was exposed in vitro to tar extracts prepared from either tobacco, marijuana, or placebo marijuana cigarettes. Marijuana tar induced higher levels of CYP1A1 messenger RNA (mRNA) than did tobacco tar, yet resulted in much lower CYP1A1… CONTINUE READING