Induction and regulation of matrix metalloproteinase-12in human airway smooth muscle cells

  title={Induction and regulation of matrix metalloproteinase-12in human airway smooth muscle cells},
  author={Shaoping Xie and Razao Issa and Maria B Sukkar and Ute Oltmanns and Pankaj K Bhavsar and Alberto Papi and Gaetano Caramori and Ian M. Adcock and Kian Fan Chung},
  journal={Respiratory Research},
  pages={148 - 148}
BACKGROUND The elastolytic enzyme matrix metalloproteinase (MMP)-12 has been implicated in the development of airway inflammation and remodeling. We investigated whether human airway smooth muscle cells could express and secrete MMP-12, thereby participating in the pathogenesis of airway inflammatory diseases. METHODS Laser capture microdissection was used to collect smooth muscle cells from human bronchial biopsy sections. MMP-12 mRNA expression was analysed by quantitative real-time RT-PCR… CONTINUE READING


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