Induction and patterning of the primitive streak, an organizing center of gastrulation in the amniote

@article{Mikawa2004InductionAP,
  title={Induction and patterning of the primitive streak, an organizing center of gastrulation in the amniote},
  author={Takashi Mikawa and Alisa M. Poh and Kristine A Kelly and Yasuo Ishii and David E. Reese},
  journal={Developmental Dynamics},
  year={2004},
  volume={229}
}
The primitive streak is the organizing center for amniote gastrulation. It defines the future embryonic midline and serves as a conduit of cell migration for germ layer formation. The migration patterns of endodermal and mesodermal precursors through the streak have been studied in great detail. Additional new breakthroughs recently have revealed the cell biological and molecular mechanisms that govern streak induction and patterning. These findings include (1) identification of the ontogeny… 

"Induction and Patterning of the Primitive Streak, an Organizing Center of Gastrulation in the Amniote" (2004), by Takashi Mikawa, Alisa M. Poh, Kristine A. Kelly, Yasuo Ishii, and David E. Reese

By gaining a better understanding of the function of the primitive streak and the main axes of development, the authors hope to contribute to the bigger picture of amniote embryology—that is, the early development of reptiles, birds and mammals inside the amniotic fluid.

Multicellular rosette formation during cell ingression in the avian primitive streak

It is proposed that organization into higher order structures facilitates cell ingression during gastrulation and is investigated the cytoskeletal architecture during these morphogenetic processes and characterized microtubule organisation in whole chick embryos.

Modeling Gastrulation in the Chick Embryo: Formation of the Primitive Streak

In this model the formation of large scale cell flows requires an additional mechanism that coordinates and aligns the motion of neighboring cells, and this finding supports a mechanism in which streak tip cells produce a diffusible morphogen which repels cells in the surrounding epiblast.

Cell movement during chick primitive streak formation.

Regulation of cell migration during chick gastrulation.

Collective Epithelial and Mesenchymal Cell Migration During Gastrulation

It is argued that instructive cell-cell signaling and directed chemotactic movement responses to these signals are instrumental in the execution of all phases of gastrulation.

Eph Regulates Dorsoventral Asymmetry of the Notochord Plate and Convergent Extension-Mediated Notochord Formation

The data support a model in which in ascidian embryos Eph-dependent dorsoventral polarity of notochord precursors plays a crucial role in mediolateral cell intercalation and is required for properNotochord morphogenesis.
...

References

SHOWING 1-10 OF 105 REFERENCES

Epiblast and primitive-streak origins of the endoderm in the gastrulating chick embryo

It is shown that between stages 3a/b and 4, the intraembryonic definitive endoderm receives contributions mainly from the rostral half of the primitive streak, and that endodermal movements parallel those of ingressing adjacent mesodermal subdivisions.

Molecular Genetic Control of Axis Patterning during Early Embryogenesis of Vertebrates

  • G. Schoenwolf
  • Biology
    Annals of the New York Academy of Sciences
  • 2000
Formation of the axis and its subsequent patterning to establish the tube‐within‐a‐tube body plan characteristic of vertebrates are initiated during gastrulation, and the molecular basis for axis formation is beginning to become understood.

New insights into critical events of avian gastrulation

By following labeled cells over time, it is established that the timing of movement of epiblast cells toward and into the primitive streak is established, providing direct evidence that cell–cell intercalation occurs within the primitive streaks during its progression.

Mesoderm movement and fate during avian gastrulation and neurulation

The results confirm and extend the previous avian prospective fate maps, increasing the understanding of the movement and fate of cells of the gastrula and neurula stages.

Locations of the ectodermal and nonectodermal subdivisions of the epiblast at stages 3 and 4 of avian gastrulation and neurulation.

It is revealed that the ingression of cardiogenic cells through the primitive streak occurs prior to late gastrula stages, suggesting that contributions of epiblast to the heart at later stages are artifactual.

Induction of primitive streak and Hensen's node by the posterior marginal zone in the early chick embryo.

It is concluded that the marginal zone posterior to Koller's sickle can induce a streak and node, without contributing cells to the induced streak.

Chordin regulates primitive streak development and the stability of induced neural cells, but is not sufficient for neural induction in the chick embryo.

The results suggest that the regulation of BMP signalling by chordin plays a role in primitive streak formation and that chordin is not sufficient to induce neural tissue in the chick.

Cwnt-8C: a novel Wnt gene with a potential role in primitive streak formation and hindbrain organization.

A novel member of the Wnt gene family, Cwnt-8C, which is expressed prior to gastrulation in the posterior marginal zone, the primitive streak and Hensen's node, is identified, potentially involved in the regulation of axis formation and hindbrain patterning.

Misexpression of chick Vg1 in the marginal zone induces primitive streak formation.

It is shown that chick Vg1 (cVg1), a member of the TGFbeta family of signalling molecules whose homolog in Xenopus is implicated in mesoderm induction, is expressed in the PMZ of prestreak embryos and can mediate ectopic axis formation in the chick by inducing new cell fates.
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