Induction and nuclear accumulation of fos and jun proto-oncogenes in hypoxic cardiac myocytes.

@article{Webster1993InductionAN,
  title={Induction and nuclear accumulation of fos and jun proto-oncogenes in hypoxic cardiac myocytes.},
  author={Keith A. Webster and Daryl J. Discher and Nanette Hahr Bishopric},
  journal={The Journal of biological chemistry},
  year={1993},
  volume={268 22},
  pages={
          16852-8
        }
}
Hypoxic and ischemic stresses cause a series of well documented changes in myocardial cells and tissues, including increased anaerobic glycolysis, loss of contractility, changes in lipid and fatty acid metabolism, and eventual irreversible membrane damage and cell death. In this article we describe changes in the expression and regulation of the proto-oncogenes fos and jun in cardiac myocytes exposed to severe hypoxia. The mRNAs encoding c-Fos, c-Jun, Jun-D, and Jun-B were induced within 1 h of… CONTINUE READING
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