Induction and maintenance of the neuronal cholinergic phenotype in the central nervous system by BMP-9.

@article{LpezCoviella2000InductionAM,
  title={Induction and maintenance of the neuronal cholinergic phenotype in the central nervous system by BMP-9.},
  author={I. L{\'o}pez-Coviella and B. Berse and R. Krauss and R. Thies and J. Blusztajn},
  journal={Science},
  year={2000},
  volume={289 5477},
  pages={
          313-6
        }
}
Bone morphogenetic proteins (BMPs) have multiple functions in the developing nervous system. A member of this family, BMP-9, was found to be highly expressed in the embryonic mouse septum and spinal cord, indicating a possible role in regulating the cholinergic phenotype. In cultured neurons, BMP-9 directly induced the expression of the cholinergic gene locus encoding choline acetyltransferase and the vesicular acetylcholine transporter and up-regulated acetylcholine synthesis. The effect was… Expand
Induction of a dopaminergic phenotype in cultured striatal neurons by bone morphogenetic proteins.
Bone morphogenetic protein 9 induces the transcriptome of basal forebrain cholinergic neurons.
Microglial regulation of cholinergic differentiation in the basal forebrain
BMP mRNA and protein expression in the developing mouse olfactory system
BMP9 Protects Septal Neurons from Axotomy-Evoked Loss of Cholinergic Phenotype
BMP-Smad 1/5/8 signalling in the development of the nervous system
...
1
2
3
4
5
...

References

SHOWING 1-10 OF 39 REFERENCES
Bone morphogenetic proteins in the nervous system
...
1
2
3
4
...